General Information

  • ID:  hor000587
  • Uniprot ID:  P41839
  • Protein name:  Callatostatin-2
  • Gene name:  NA
  • Organism:  Calliphora vomitoria (Blue bottle fly) (Musca vomitoria)
  • Family:  Allatostatin family
  • Source:  Animal
  • Expression:  Brain, subesophageal ganglion, retrocerebral complex, thoracico-abdominal ganglion, peripheral neurosecretory system and intestine.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Calliphora (genus), Calliphorinae (subfamily), Calliphoridae (family), Oestroidea (superfamily), Calyptratae, Schizophora, Cyclorrhapha, Eremoneura, Muscomorpha (infraorder), Brachycera (suborder), Diptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  LNEERRANRYGFGL
  • Length:  14(3-16)
  • Propeptide:  DPLNEERRANRYGFGL
  • Signal peptide:  NA
  • Modification:  T14 Leucine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  inhibit juvenile hormone production
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P41839-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor000587_AF2.pdbhor000587_ESM.pdb

Physical Information

Mass: 192692 Formula: C73H115N25O22
Absent amino acids: CDHIKMPQSTVW Common amino acids: R
pI: 9.35 Basic residues: 3
Polar residues: 5 Hydrophobic residues: 4
Hydrophobicity: -124.29 Boman Index: -5529
Half-Life: 5.5 hour Half-Life Yeast: 3 min
Half-Life E.Coli: 2 min Aliphatic Index 62.86
Instability Index: 6203.57 Extinction Coefficient cystines: 1490
Absorbance 280nm: 114.62

Literature

  • PubMed ID:  8460157
  • Title:  Callatostatins: Neuropeptides From the Blowfly Calliphora Vomitoria With Sequence Homology to Cockroach Allatostatins